Methylation analysis of LINE-1 elements in canine mast cell tumours.

Assunto

Epigenetics is the study of changes in gene function that are meiotically or mitotically heritable genome. The study of its methylation pattern is used in the understanding of several neoplasms. Canine mast cell tumours represent a frequent cutaneous neoplasm presenting different degrees of malignancy, being classified according to their histological differentiation. In view of the current scientific scarcity in relation to the epigenetic pattern of neoplasms in domestic animals, this study aimed to verify whether there is correlation between the methylation pattern of LINE-1 with the different staging of canine mastocytomas according to the Kiupel classification. but without implying DNA change. LINE-1 (long interspersed nuclear element-1) is a family of related class I transposable elements in the DNA that is dispersed throughout the entire