Peri-Implant Repair Using a Modified Implant Macrogeometry in Diabetic Rats: Biomechanical and Molecular Analyses of Bone-Related Markers.
Documento
Informações
Título
Peri-Implant Repair Using a Modified Implant Macrogeometry in Diabetic Rats: Biomechanical and Molecular Analyses of Bone-Related Markers.
Título (EN)
Peri-Implant Repair Using a Modified Implant Macrogeometry in Diabetic Rats: Biomechanical and Molecular Analyses of Bone-Related Markers.
Autor(es)
Hugo Robertson Sant’Anna, Marcio Zaffalon Casati, Mounir Colares Mussi, Fabiano Ribeiro Cirano, Suzana Peres Pimentel, Fernanda Vieira Ribeiro and Mônica Grazieli Corrêa
Instituição
Universidade Paulista
Tipo
Artigo
Publicado em
Materials (Basel). 2022 Mar 21;15(6): 2317.
Resumo (EN)
Abstract
DM has a high prevalence worldwide and exerts a negative influence on bone repair around dental implants. Modifications of the microgeometry of implants have been related to positive results in bone repair. This study assessed, for the first time, the influence of an implant with modified macrodesign based on the presence of a healing chamber in the pattern of peri-implant repair under diabetic conditions. Thirty Wistar rats were assigned to receive one titanium implant in each tibia (Control Implant (conventional macrogeometry) or Test Implant (modified macrogeometry)) according to the following groups: Non-DM + Control Implant; Non-DM + Test Implant; DM + Control Implant; DM + Test Implant. One month from the surgeries, the implants were removed for counter-torque, and the bone tissue surrounding the implants was stored for the mRNA quantification of bone-related markers. Implants located on DM animals presented lower counter-torque values in comparison with Non-DM ones, independently of macrodesign (p < 0.05). Besides, higher biomechanical retention levels were observed in implants with modified macrogeometry than in the controls in both Non-DM and DM groups (p < 0.05). Moreover, the modified macrogeometry upregulated OPN mRNA in comparison with the control group in Non-DM and DM rats (p < 0.05). Peri-implant bone repair may profit from the use of implants with modified macrogeometry in the presence of diabetes mellitus, as they offer higher biomechanical retention and positive modulation of important bone markers in peri-implant bone tissue.
Palavras-chave
bone repair; dental implants; gene expression.
Fonte/doi
Direito de Acesso
Acesso restrito
Financiamento
This study was supported by Implacil de Bortoli and by National Council of Technological and Scientific Development (CNPq), Brasília, DF, Brazil (Process 441518/2014-1).