Resumo (EN)
Rett syndrome (RS) is a severe neurological developmental disorder, and its incidence is 1: 10,000 female births, one of the most common genetic causes of severe mental retardation in females. The development is apparently normal in the first six to 18 months of life until regression occurs cognitive, social and motor skills. The progression and severity of the disorder are assessed and classically divided into stage I, early stagnation, stage II, rapidly destructive, stage III, stationary pseudo, and stage IV, the late motor deterioration. Mutations in the X-linked gene 2 protein binding of methyl-CpG (MECP2) is present in most patients with MR. The physical therapy is quite effective, as it improves or maintains the funcional, sensory and motor functions in SR. These benefits that greatly impact quality of life of individuals with severe disabilities.