Resumo (EN)
Objective – To check polyphenols role in DA neuroprotection. Methods – Original articles reporting “in vivo” experiments on transgenic mice in English and Portuguese, published from 2007 to 2014 in Pubmed, Scieloand Lilacsdatabases. Results – Studies have found that oral administration of various types of polyphenolic compounds showed possible protective effect against AD in transgenic mice, by acting on the inflammation caused by deposition of amyloid plaque, decreasing such inflammation and preventing the progression of AD. Conclusion – We conclude that polyphenols administered orally have a neuroprotective role on AD, mitigating the severity of the symptoms, and contributing to the attenuation of the progression of the disease.