Resumo (EN)
The present study aims to describe neurotoxic effects of malathion on the human central nervous system (CNS). Methods – A bibliographic survey were performed using papers from Google Scholar, SciElo, Pubmed, Lilacs and Repositório CAPES, between 2002 to 2020. The following key words were used: “malathion”, “CNS”, “nervous system”, “intoxication”, “insecticides” and “organophosphate”. Malathion is an organophosphorus with a short mid-life of only 32 hours, depending on their availability, the insecticide is classified as category “Class II” (highly toxic). One of the main effects is the enzymatic inhibition of cholinesterase’s causing the accumulation of the metabolites and several neurological syndromes. Despite the liberated use and moderate toxicity, malathion causes significant damage to the CNS and should be used only with care and to avoid pesticide poisoning incidents