Efeito dos extratos aquosos do tomate e do alho sobre o tumor ascítico de Ehrilch

Resumo (EN)

With the intention of studying the action of bioactive compounds present in tomatoes e garlic for the prevention and for the development of the experimental tumor of Ehrlich in small rats Balb-c, the same were used, males between the weight of 25 and 30 grams that were separated indiscrimately into four different experimental groups: Control Group (CG) (n=8): these received only water, Tomato Group (TG) (n=8) these received reduction of tomato paste of 2%, Garlic Group (GG) (n=8) these received reduction of garlic of 2%, Garlic/Tomato Group (GTG) (n=8) these received reduction of garlic and tomato, both of 2% for each compound. During twenty-four days (24), the animals of groups TG, GG, and GTG received the bioacive compounds offered ad libitum, as the only source of water and the group CG receied only sterlized water. ln the 25th day, all animals were inserted with the experimental tumor of Ehrlich (0,2 mi of solution that contains 5x1 O 7 cells through intraperitoneal) and continued to receive the bioactive compounds. ln the 12th day after the insertion of the tumor, all animals were submitted to euthanasia by deslocating their cervical column, then the the ascitic acid was collected and the tumeric cells were counted in the Neubauer chamber. The production of NO was determined by the method of Griess, by measuring the nitrits. The animals of the group GTG presented less gains in weight when compared to all other groups, in the period prior to the insertion of the tumor. After the insertion of the experimental tumor of Ehrlich, there was no statistical difference that could be considered significant in the gains of weight among all groups researched. The groups that received the experimental treatment - garlic, tomato and garlic+tomato, had a larger tumoral growth in relation to the control group. The values of NO produced were similar among all experimental groups. lt is possible to conclude that the bioactive compounds of the garlic and/or tomato increase the growth of Ehrilch ascites tumor.