Interacciones moleculares de los ARN largos no codificantes en la encefalopatía hepática asociada a la cirrosis: una revisión sistemática

Resumo (EN)

Introduction.Hepatic encephalopathy (HE) is a complex and potentially reversible neurological syndrome resulting from acute or chronic liver diseases, characterized by neuropsychiatric, cognitive, motor, and neuromuscular coordination alterations. Studies on the role of long non-coding RNAs (lncRNAs) in encephalopathy are still limited. Therefore, this systematic review describes the role of lncRNAs in the different signaling pathways involved in HE in cirrhotic patients. Method.The PubMed, Web of Science, and LILACS databases were used to identify studies. Studies with mice and/or cirrhotic patients with HE that evaluated the expression of lncRNAs and their interaction mechanisms were included. Results.Of the six included studies, 11 lncRNAs were associated with HE (SIX3OS, lnc240, AL137857.1, lnc-FAM84B-8, lnc-SAMD3-1, ZFAS1, GAS5, uc007pjf.1, ENSMUST00000167589, uc007hha.1, ENSMUST00000124047). Three studies were conducted with cirrhotic patients withHE, while three others used mice. The results varied between expression and silencing associated with regulatory mechanisms. In the interaction network between the lnc240/miR-1264-5p/MEF2C pathways, it was indicated that lnc240 can regulate MEF2C expression via miR-1264-5p, affecting hippocampal synaptic plasticity. Silencing of SIX3OS1 increased miR-743b-3p expression, reduced AQP1 levels, and attenuated hyperammonemia-induced abnormal dendritic spine development, reinforcing the relevance of this interaction. Conclusion.This is the first systematic review to evaluate the role of lncRNAs and their interaction networks in HE in cirrhotic patients. Several lncRNAs regulate pathways by being expressed or silenced, influencing miRNAs and mRNAs