Efeito combinado do óleo essencial de Cinnamomum zeylanicum Blume e miconazol sobre Candida spp

Resumo (EN)

Objective – To evaluate the combined effect of the essential oil (EO) of Cinnamomum zeylanicum Blume and miconazole against Candida spp. Methods – It was determined the minimum Inhibitory Concentration (MIC) of both products and the Fractional Inhibitory Concentration index (FIC) by means of the Checkerboard Test. Data were analyzed descriptively. Results – When assessed alone, C. zeylanicumand miconazole showed MIC of 312.5μg/mL and 32μg/mL, respectively, against all strains tested. After combination, it was observed that the EO inhibited the yeast growth at a concentration of 39μg/mL. On the other hand, miconazole combined showed MIC of 128, 32 and 32μg/mL against strains of C. albicans, C. tropicalis and C. krusei, respectively. These results indicate FIC values of 4.1248 (antagonism), 1.1248 (indifference) and 1.1248 (indifference), respectively, for C. albicans, C. tropicalisand C. krusei. Conclusions – The combination between C. zeylanicumessential oil and miconazole was not found to be an advantageous possibility for growth inhibition of Candida spp. The combination of this EO with other standard antifungals should be considered in further trials.