Resumo (EN)
Objective – To determination basic structure and molecular modeling by comparative means of gyroxin, a serinoproteases trombine-like isolated from the Crotalus durissus terrifius venom. Methods– Analysis of similarity of primary and secondary structures generated through logaritmic and probabilistic systems to find a protein model of the same family with capacity to be used as template to create tridimensional comparative structures of the selected protein. Results– The gyroxin is a 241 aminoacids protein, of acid qualities, instable and have better activity in water solutions. It has 26.1kDa of molecular weight and 6 probable dissulfide bonds. Conclusions – Gyroxin is a trombine-like protein acting to dissolve blood clots and her structure-activity study may bring new drugs to treat pulmonary embolism, cardiac arrest and lower members tromboses. New studies appoint the interaction between gyroxin and PAR-1 astrocytes receptors who may indicate a new class of neurodegeneratives syndromes drugs, such as Parkinson’s syndrome.