Efeito de uma membrana bioativa sobre a regeneração óssea guiada de defeitos críticos de calvária

Resumo (EN)

Guided bone regeneration (GBR) is an approach that has become increasingly well known for promoting successful regenerative treatment. This technique consists of using physical barriers to isolate the area to be regenerated from the non-osteogenic influence of gingival connective tissue cells, protecting the clot formed in the space between the barrier and the pre-existing bone tissue. This study aimed at determining the effect of guided bone regeneration using a membrane with polylactic acid polymers by polylactic acid polymers), polycaprolactone (PCL) and polyethylenel (PEG) associated with the incorporation of bioactives [beta-tricalcium (β -TCF), hydroxyapatite (HA) and nano-HA], in the repair of calvaria repair in rats. For this, 21 rats were divided into groups: Test (=7): Bioactive Membrane; Positive Control (n=7): BioGide® Membrane; Negative Control (n=7): no treatment. Two critical defects were created in each animal at the start of the study (day 0). The animals were euthanized after 4 weeks of defects creation and the calvaria defects were processed for histological and histomorphometric analysis. The results indicate that the positive control group (Bio-Gide) presented grater closure of the bone defects compared to the test group (Bioactive Membrane) and the negative control (no treatment). The use of the bioactive membrane did not promote bone generation (GBR) of calvaria defects in rats.